Computational and Systems Biology

Computational methods for studying cellular differentiation using single-cell RNA-sequencing ?

Yeo, Hui Ting Grace. (Massachusetts Institute of Technology, 2020)

Single-cell RNA-sequencing (scRNA-seq) enables transcriptome-wide measurements of single cells at scale. As scRNA-seq datasets grow in complexity and size, more complex computational methods are required to distill raw ...
Optimizing scientific innovation by learning on knowledge graph dynamics ?

Weis, James W.(James Woodward) (Massachusetts Institute of Technology, 2020)

The integration of data-driven methodologies, including techniques from artificial intelligence and network science, into the research process and funding ecosystem is an exciting, potentially paradigm-changing opportunity ...
Evolutionary and structural signatures of protein-coding function : synonymous acceleration, read-through, and structural impact of mutations ?

Wolf, Maxim,Ph. D.(Maxim Y.)Massachusetts Institute of Technology. (Massachusetts Institute of Technology, 2019)

In this thesis I observe evolutionary signatures in coding regions to: (1) understand the sources of highly mutable coding regions in mammals; (2) to elucidate a new candidate function for a stop codon readthrough candidate ...